Wondering why your pain hurts more than it should? That might be a complex regional pain syndrome. We understand living with an uncommon disease can be quite overwhelming, it can take a toll on your mental health. However, knowing the disease and how it can affect your life can help you navigate through the condition. Read on to know what is complex regional pain syndrome, its symptoms, causes, and treatment options you have. A Singapore Chiropractor explains!
What is Complex Regional Pain Syndrome (CRPS)?
Complex regional pain syndrome (CRPS) is a chronic and debilitating condition that causes severe and persistent pain. It usually affects only one limb and rarely causes pain in other parts of the body such as the face.
CRPS is followed by an injury, such as surgery or fracture. Normally, the pain goes away as the body heals. But with this condition, it lasts longer and might get worse with time. The pain after injury is far stronger and more intense than it should be, and it might result from small sensory stimuli such as light touch.
Studies suggest that most people with CRPS still have some degree of pain even after one year. In some cases, the pain is usually so intense that it prevents people from doing their daily life activities. According to the McGill Pain Index, the pain in CRPS rates higher than that of cancer pain and amputation of a digit.
Most people with complex regional pain syndrome usually recover and a few might redevelop it. Stats show that women are three times more at high risk of CPRS than men. It can affect people of any age but usually occurs between the ages of 50-70.
Causes of Complex Regional Pain Syndrome
The exact mechanism of CRPS is not known. However, experts believe that CRPS develops due to the dysfunction in peripheral and central nervous system. These systems are responsible for passing information from the brain and spinal cord to different body parts.
The injury to nerves or trauma might damage the sensory or autonomic nerve fibers that carry the sensation of pain, hot and cold. This results in improper communication that generates excess pain signals that our nervous system can’t regulate.
Research also suggests that CRPS might develop due to inflammatory reactions in the nervous system. Further, the release of cytokines, chemicals released in response to trauma, produced by the immune system might contribute to the syndrome.
Here are the following events that may lead to the development of CRPS:
- Bone fracture
- Surgery
- Burns, bruises or cuts
- Sprain or strain
- Heart Attack
- Infections
However, it’s not essential that everyone who will get these injuries will develop complex regional pain syndrome.
Types of
Complex Regional Pain Syndrome
Complex regional pain syndrome is usually categorized into two types.
● Complex Regional Pain Syndrome Type 1
It is also called reflex sympathetic dystrophy. It occurs without any major nerve damage. It usually results from injury or trauma that doesn’t directly cause nerve damage. Almost 90% of cases develop CRPS-1 and have nociceptive pain.
● Complex Regional Pain Syndrome Type 2
CRPS-2, also known as causalgia, has similar symptoms to type 1. The only difference is that it arises from distinct nerve damage.
Risk Factors for CRPS
You are more likely to develop the condition if you possess the following complex regional pain syndrome risk factors:
- Family history of CRPS
- History of psychiatric, substance and headache disorder
- Diabetes or any other disease that can damage your nerves
- Poor blood circulation
- Inflammatory diseases
Complex Regional Pain Syndrome Symptoms
The severity and duration of CRPS symptoms vary from person to person. You may develop symptoms within 3 to 4 weeks after injury, and sometimes these can appear without a known cause.
You might feel burning, stinging, tearing and throbbing pain in the affected area. Other symptoms of CRPS include:
- Swelling in the affected limb
- Rapid hair or nail growth or no growth at all
- Increased sensitivity to pain
- Hyperalgesia, intense pain resulting from stimuli that are usually not painful
- Changes in skin temperature ranging from extremely warm to cold
- Numbness
- Abnormal sweating of the affected area
- Decreased range of motion in the affected limb
- Joint stiffness in the affected limb
- Muscle spasms
- Tremors
- Dramatic changes in skin color, ranging from pale blotchy to bruised red
- Changes in skin texture
Diagnosis of
Complex Regional Pain Syndrome
It is usually misdiagnosed as it is an uncommon condition. There are no specific tests to diagnose the complex regional pain syndrome. Your doctor will review your medical history and ask about the symptoms you have. He may look for:
- Any change in the texture and appearance of the skin
- Any condition that causes pain
- Your sensitivity to pain or touch
Your healthcare provider will first rule out any other condition to confirm the diagnosis. He might order the following tests:
- MRI scan to rule out possible underlying conditions within bones
- X-rays to detect bone loss within later stages of the disease
- Blood test to look for any sign of inflammation or infection
- Sweat production test to measure the amount of sweat in the limbs
- Thermography to measure temperature changes in different skin parts
- Nerve conduction studies to measure the electrical activity of nerves
Your doctor might use Budapest criteria to diagnose the condition. It is the most widely accepted diagnostic criteria for complex regional pain syndrome. It requires the presence of symptoms from these four categories
- Sensory, including increased sensitivity to stimulation and pain from stimuli that usually don’t cause pain
- Vasomotor that includes changes in skin color or temperature
- Motor/trophic that includes decreased range of motion and changes in nail or hair growth
- Sudomotor that includes the report of oedema or sweating changes
You must have at least one symptom from each category. At the time of evaluation, you must have at least one symptom in two or more categories. Additionally, there should be no other condition that explains these symptoms.
Complex Regional Pain Syndrome Treatment
There is always a chance that a patient may recover on its own without any treatment. But considering the debilitating nature of the disease, it’s important to start the treatment as soon as possible. The sooner you start the treatment, the better your chances of recovery. It not only improves symptoms but also restores the functionality of the affected limb and prevents disability.
Here are the treatment options for complex regional pain syndrome:
Medications
No drugs are specifically approved for the treatment of CRPS. Your healthcare professional might prescribe these medications to manage your symptoms.
● Non-Steroidal Anti-inflammatory Drugs
Drugs, such as Naproxen, Ibuprofen and Tylenol, may help manage pain and inflammation associated with the condition.
● Opioids
Over-the-counter drugs won’t work for severe pain. In this case, your healthcare professional might prescribe stronger painkillers that belong to the class of drugs called opioids. Examples include fentanyl, oxycodone and morphine.
● Corticosteroids
Corticosteroids, such as prednisolone, might help manage inflammation and improve the range of motion of affected limbs.
● Anticonvulsants
These groups of medications are usually used to treat epilepsy. However, they can also help manage nerve pain. Gabapentin and pregabalin are the most widely used anticonvulsants for complex regional pain syndrome.
● Tricyclic Antidepressants
Medicines, such as amitriptyline and nortriptyline, also help manage neuropathic pain.
● Calcium Channel Blockers
These drugs are used for the management of vasomotor symptoms due to their ability to modulate neural signaling and vascular tone.
Physical Therapy
Physical therapy is a significant part of the treatment of complex regional pain syndrome. It may help increase blood flow to the affected limb, thus improving flexibility and function. It also prevents or reverses complications, such as muscle atrophy or joint stiffness.
It improves your overall health and the ability to perform daily tasks. Your physical therapist might use the following techniques:
● Desensitization
It is done to reduce hypersensitivity to pain and to improve your tolerance to various sensations.
● Graded Motor Imagery
This therapy helps retrain your brain and reduce pain and disability.
● Functional Training
It helps you learn safe, controlled movements that remove the stress from the affected limb and improve your ability to perform daily tasks.
● Manual Therapy
It helps reduce pain and improve the function of the affected limb by addressing muscle spasms and disuse atrophy.
● Mirror Therapy
It uses a mirror to trick the brain into perceiving movement in the impaired limb, when, in fact, movement is occurring in the healthy limb. This technique helps rewire the brain and correct the neural abnormality associated with CRPS.
Psychological Support
Living with complex regional pain syndrome is quite challenging and patients may experience certain psychological problems, such as anxiety and depression. It can interfere with your recovery and might deteriorate your health further, so it’s important to look after your mental well-being.
Seeking psychological support can help you recover and improve your symptoms. Research suggests that cognitive behavioral therapy is effective in managing chronic pain conditions. It has been shown to alleviate pain, improve mood and boost overall function in patients with CRPS.
The goal of cognitive behavioral therapy is to make you understand how your thoughts, behavior and feelings affect each other. By understanding your condition and how you feel about it, CBT can help you manage your symptoms better. CBT is particularly beneficial when used as a part of a physical rehabilitation programme.
Interventional Therapies
These are minimally invasive procedures that target the source of your pain to provide relief and improve your quality of life. These procedures include:
● Sympathetic Nerve Blocks
These are considered the first-line treatment options for the management of complex regional pain syndrome. Your healthcare provider will inject anesthetic drugs to block the pain fibers in the affected nerve, thus providing temporary relief. Your doctor will inject anesthesia on the side of your neck (stellate ganglion block) or in your lower back (lumbar sympathetic block).
● Dorsal Root Ganglion Stimulation
It targets the dorsal root ganglion, which acts as a relay center and sends pain signals from the affected limb to the brain. The procedure involves sending electrical impulses to the dorsal root ganglion, thus modulating the pain signals before they reach the brain.
● Spinal Cord Stimulation
In this procedure, your healthcare provider will implant a small device under the skin near the spine. This device will generate electrical impulses and send them to nerves in the spinal cord. This, in turn, reduces pain signals from reaching the brain.
● Intrathecal Delivery
In this procedure, your doctor will implant a small pump under the skin that delivers medication directly to the spinal cord. This technique allows for a smaller dose of medication to be used as it delivers the drug directly to the source of pain.
Tips For Living With Complex Regional Pain Syndrome
Complex regional pain syndrome is a difficult condition to deal with. Here are some practical tips that can help you navigate life with CRPS:
● Embrace Acceptance and Educate Yourself
Coming to terms with your condition is the first and foremost thing. It doesn’t happen overnight but it is ok to have good and bad days. Once you accept the condition, educate yourself about the disease, so you can make informed decisions about your health.
● Stay Active Within Your Limits
It’s important to exercise every day as it helps improve circulation to the affected limb. But, it’s also important to listen to your body. Remember, it’s not the intensity but the consistency of staying active within your comfort zone.
● Engage in Your Hobbies
Engaging in your favorite activity, whether it’s painting, crafting or gardening, can help you distract from the pain and bring you a sense of normalcy and joy.
● Lean on Your Support System
Connect with the people who understand what you are going through, whether through support groups or online communities. It can provide you with invaluable emotional support and practical advice.
● Make Lifestyle Adjustments
You can take these steps to help improve your symptoms at home:
- Eating a diet rich in anti-inflammatory foods, such as fruits, vegetables and whole grains, can help reduce pain and inflammation.
- Meditating often can help you navigate through stress and reduce the perception of pain.
- Try to elevate your affected limb while sleeping or resting. It helps excess fluid return to your heart.
- Wear compression stockings as they may reduce inflammation.
● Be Proactive With Your Treatment Plan
Work closely with your healthcare provider to manage your conditions. Don’t hesitate to ask any questions about your treatment and medications.
How Singapore Chiropractic Care Can Help People With Complex Regional Pain Syndrome?
Singapore Chiropractic care is an effective complementary option for people with complex regional pain syndrome. Singapore Chiropractic care involves spinal adjustments that improve the communication between the brain and the body. This improved communication might help reduce the misinterpretation of pain signals.
Complex regional pain syndrome leads to decreased range of motion and stiffness. Singapore Chiropractic care can help improve the motion of affected limbs and flexibility. Additionally, it reduces inflammation and manages other symptoms of CRPS.
Our team at Vitality Chiropractic in Singapore specialize in upper cervical Chiropractic care. We work closely with each patient and provide personalized care tailored to your individual needs. If you are seeking relief from chronic pain, contact us right now to schedule your appointment.
REFERENCES
- Birklein, F. (2005). Complex regional pain syndrome. Journal of Neurology, 252(2), 131–138. https://doi.org/10.1007/s00415-005-0737-8
- Lee, B. H., Scharff, L., Sethna, N. F., McCarthy, C., Scott-Sutherland, J., Shea, A. M., Sullivan, P., Meier, P. M., Zurakowski, D., Masek, B. J., & Berde, C. B. (2002). Physical therapy and cognitive-behavioral treatment for complex regional pain syndromes. The Journal of Pediatrics, 141(1), 135–140. https://doi.org/10.1067/mpd.2002.124380
- Misidou, C., & Papagoras, C. (2019). Complex Regional Pain Syndrome: An update. Mediterranean Journal of Rheumatology, 30(1), 16–25. https://doi.org/10.31138/mjr.30.1.16
- RSDSA. (2023, April 20). Definition of CRPS – RSDSA. RSDSA – 40 Years of Helping Those Affected by CRPS. https://rsds.org/living-with-crps/definition-of-crps/
- Website, N. (2022, November 4). Complex regional pain syndrome. nhs.uk. https://www.nhs.uk/conditions/complex-regional-pain-syndrome/
Written by
Shaan Rai (Chiropractor, Singapore)
Shaan is a British Chiropractor, based in Singapore. He is an Alliance of Chiropractic (AOC) registered Singapore Chiropractor, completing a 5 year course at AECC (UK), attaining his Masters in Chiropractic. He is the Vice President and Chairman for Outreach & Charity for Alliance of Chiropractic (AOC) and is the founder of Vitality Chiropractic Singapore. He developed the NeuroPro method, combining Upper Cervical techniques with Functional Neurology Rehab, with published research coming in 2025.
